Microbiological monitoring of pharmaceutical water systems

06/26/2017 13:50:19 PM

Water is widely used in pharmaceutical manufacturing; either as a raw material, as an ingredient, or as a final product. Water is also used for rinsing equipment or for the preparation of disinfectants and detergents. These applications require ...

MHRA GMP Inspection Deficiency Data Trend 2016

06/25/2017 07:30:15 AM

The GMDP Inspectorate has improved the way of gathering the inspection deficiency data for 2016. The new data trending can allow industries to identify:The severities and frequencies by the EU GMP referencesThe overall number of deficiencies ...

Silver Bullet Against MRSA: Silver Ion-coated Devices

06/24/2017 07:30:24 AM

Methicillin-resistant Staphylococcus aureus (MRSA) infections are caused by a type of staph bacteria that has become resistant to the antibiotics used to treat ordinary staph infections. The rise of MRSA infections is limiting the treatment ...

Chemical purity regulatory findings

06/23/2017 13:52:47 PM

New Applications for Certificates of Suitability (CEP) for chemical purity (Top 10 deficiencies)The EDQM has issued a document that summarises the ten most frequent questions raised after the initial evaluation of new applications for Certificates ...

Guidance on quality of water for pharmaceutical use

06/22/2017 07:00:26 AM

Concept paper on the need for revision of note for guidance on quality of water for pharmaceutical useUp to now, the production of Water for Injections (WFI) had been limited to distillation only. The revision of the monograph for Water for ...

Why we get diarrhea

06/21/2017 17:07:48 PM

Does diarrhea serve a purpose? Does it actually help clear the bacteria causing a gastrointestinal infection, or is it merely a symptom of disease that should be prevented as much as possible? In a new study from Brigham and Women's Hospital, ...

Test for Abnormal Toxicity

06/21/2017 07:00:29 AM

The scientific validity and rationale of the test for abnormal toxicity has been the subject of debate for some time in Europe. The test was originally developed for detecting external contaminants in biological products, but over time the ...

FDA - Burkholderia cepacia complex poses a contamination risk

06/20/2017 07:00:10 AM

FDA warned drug manufacturers on May 22, 2017 about a series of product recalls involving Burkholderia cepacia complex (BCC) contamination. BCC is a water-borne pathogen that can be found in pharmaceutical water systems. According to FDA, it ...

Risk assessment and pharmaceutical processing hazards

06/19/2017 07:00:11 AM

Pharmaceutical medicines are expected to be efficacious and to perform according to the product licence or as directed by the medical practitioner. Medicines are also expected to be safe, and the basis of a safe medicine is one that has been ...

Continuous Manufacturing Provides Many Benefits for the Pharmaceutical Industry

06/18/2017 10:06:18 AM

Continuous manufacturing is a process people adopted since the beginning of the industrial revolution — production for a product continues for months or years uninterrupted, creating an unbroken supply chain. It’s used in everything from ...

Antibiotics are a potential link to bowel cancer precursor

06/18/2017 09:27:23 AM

A new study has found that people who take antibiotics over long time are more at risk of developing growths on the bowel that could be a precursor to cancer.The research forms part of a wider line of scientific inquiry about the effect that ...

Can airborne viruses survive in water?

06/17/2017 07:30:27 AM

A new study challenges the tenet that herpes viruses, like most enveloped viruses, are relatively unstable outside their host. Under a variety of conditions equine herpesvirus remained stable and infectious over a three week period. This suggests ...

Foods as a potential source of spread of Clostridium difficile

06/16/2017 07:30:28 AM

Foods should be investigated as a potential source of spread of Clostridium difficile, according to research presented at the 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID).C. difficilecauses gut infections ...

Ocean acidification impairs the nitrogen-fixing bacteria

06/15/2017 07:00:30 AM

While increased carbon dioxide levels theoretically boost the productivity of nitrogen-fixing bacteria in the world's oceans, because of its "fertilizing" effect, a new study reveals how increasingly acidic seawater featuring higher levels of ...

Guide to the preparation, use and quality assurance of blood components (new version)

06/14/2017 08:00:07 AM

The EDQM have issued the 19th Edition of the ‘Guide to the preparation, use and quality assurance of blood components’ (Blood Guide). The 19th Edition of the Guide contains an updated version of the Good Practice Guidelines to fully reflect ...

Novel antibiotic resistance gene in milk

06/13/2017 07:30:15 AM

A new antibiotic resistance gene has been found in bacteria from dairy cows. This gene confers resistance to all beta-lactam antibiotics including the last generation of cephalosporins used against methicillin-resistant Staphylococcus aureus. ...

Chronic fatigue syndrome linked to imbalanced microbiome

06/12/2017 07:30:08 AM

Scientists at the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health have discovered abnormal levels of specific gut bacteria related to chronic fatigue syndrome/myalgic encephalomyelitis, or ME/CFS, ...

Giardiasis may be a disease of the ecology of the GI tract

06/11/2017 08:00:02 AM

Colonization by the human and animal parasite, Giardia, changed the species composition of the mouse microbiome in a way that might be harmful."This shift is generally characterized by more aerobic bacteria and less diversity of anaerobic species ...

Oldest ever microbial fossils discovered

06/10/2017 08:00:35 AM

Remains of microorganisms, said to be over 3,770 million years old, have been discovered. These remnants provide conclusive evidence of the age of one of the oldest life forms on Earth.#The discovery of the microbial fossils, in Canada, has ...

Intestinal bacteria may protect against diabetes

06/09/2017 08:00:08 AM

Medical research suggests that a high concentration of indolepropionic acid in serum helps to protect a person against type 2 diabetes. Indolepropionic acid is produced by intestinal bacteria, and it is higher with a fiber-rich diet.The new ...

Insight into pathogenic bacterium Pseudomonas aeruginosa

06/08/2017 08:00:09 AM

Researchers have identified how the pathogenic bacterium Pseudomonas aeruginosa uses tension-activated membrane channels to stop itself from swelling up and bursting when it is suddenly exposed to water. The study helps explain how this bacterium ...

Reducing animal testing in Europe

06/07/2017 08:00:22 AM

The European Medicines Agency has produced a position paper titled “Reflection paper providing an overview of the current 4 regulatory testing requirements for medicinal products for 5 human use and opportunities for implementation of the ...

Endotoxin mediated toxic anterior segment syndrome in ophthalmic products

06/05/2017 07:30:36 AM

Specifically endotoxin contamination of ophthalmic medical devices and intraocular ophthalmic products can cause ‘toxic anterior segment syndrome’ (TASS). This is an acute inflammation of the eye following ocular lens replacement surgery. ...

USP Chapter 1224 for Transfer of Analytical Methods

06/04/2017 12:29:25 PM

When validated methods are transferred between laboratories and sites, their validated state should be maintained to ensure the same reliable results in the receiving laboratory. So far there has not been an official guidance on what exactly ...

Utility Qualification Vol. II

06/04/2017 07:30:30 AM

IVT (2017) Utility Qualification Vol. II, Institute of Validation Technology, USA:The impact of water on daily activities within the production facility is significant and therefore, the ability to receive and maintain high quality water on ...

Ozonated water

06/03/2017 07:00:24 AM

Ozonated water systems are available in handwashing sinks, mobile portable ozonated water generators, and in-line skid systems. Some of the portable ozonated water units have been used to clean walls, tanks, filling lines, floors, and the actual ...

High-resolution imaging with conventional microscopes

06/02/2017 08:00:23 AM

Researchers have developed a way to make extremely high-resolution images of tissue samples, at a fraction of the cost of other techniques with similar resolution. Known as iterative expansion microscopy, relies on expanding tissue repeatedly, ...

Disrupting bacteria to better treat infections

06/01/2017 08:00:46 AM

While scientists rush to discover new antibiotics, bacteria fight back by developing new tools to resist antibiotics. In recent years, the bacteria have been winning.So this paradigm led researchers at NSU to take another look at how bacteria ...

Newly-discovered gene that makes bacteria resistant to the most powerful antibiotics

05/31/2017 07:30:18 AM

A disturbing new gene that can make normal bacteria resistant to the strongest antibiotics has been detected in Canada, it had been revealed.From The Independent:The gene, MCR-1, is notable because it produces a chemical that makes bacteria ...

How Gonorrhea manipulates the female reproductive tract

05/30/2017 07:00:19 AM

Gonorrhea is a widespread sexually transmitted disease caused when Neisseria gonorrhoeae bacteria infect the normally protective inner lining of human genital tissues. In women, the opening of the uterus, known as the endocervix, serves as a ...

Biosimilars (EDQM News)

05/28/2017 07:30:10 AM

EDQM Biosimilars: Ph. Eur. monographs are flexible and evolving standards During a seminar co-organised with the European Medicines Agency (EMA), the EDQM clarified further the role that Ph. Eur. monographs play in the assessment of biosimilars. ...

Synthetic biologists engineer inflammation-sensing gut bacteria

05/27/2017 08:00:17 AM

Synthetic biologists at Rice University have engineered gut bacteria capable of sensing colitis, an inflammation of the colon, in mice. The research points the way to new experiments for studying how gut bacteria and human hosts interact at ...

EMA: risk based prevention of cross contamination in production

05/26/2017 08:00:30 AM

The European Medicines Agency has issued a new document, with the lengthy title of “Questions and answers on implementation of risk based prevention of cross contamination in production and ‘Guideline on setting health based exposure limits ...

New assay for bioterrorism threat

05/25/2017 13:29:24 PM

Researchers in Spain are using RPA as the foundation for a highly sensitive and specific solid-phase optical assay that can detect the potential biowarfare agent, Y. pestis, in less than an hour. The enzyme-linked oligonucleotide assay (ELONA) ...

Researchers uncover how bacteria burst our cells

05/25/2017 07:00:33 AM

Scientists based in Vienna unveil the complex molecular structure that causes lethal infections by Mycobacterium tuberculosis (Mtb). Their findings might have implications for potential therapies against antibiotic-resistant tuberculosis. The ...

Too much pressure: a behavioral approach to Data Integrity

05/24/2017 07:30:08 AM

The MHRA has published an interesting article on the behavioral factors that shape data integrity.Data integrity refers to maintaining and assuring the accuracy and consistency of data over its entire life-cycle, and is a critical aspect to ...

How a beneficial gut microbe adapted to breast milk

05/23/2017 07:30:13 AM

Breast milk provides vital nutrients not only to infants, but also to beneficial microbes that inhabit the gastrointestinal tract. A new study shows that a bacterial species called Bifidobacterium longum has successfully adapted to the unique ...

Pharmig Guide to Cleanrooms

05/22/2017 07:00:17 AM

Pharmig has issued a new publication relating to cleanrooms. The guide covers good cleanroom design (together with suitable operational parameters), cleanroom specifications, microbial control, and classification according to the international ...

Giant viruses found in Austrian sewage

05/21/2017 08:00:19 AM

Giant viruses are characterized by disproportionately large genomes and virions that house the viruses' genetic material. They can encode several genes potentially involved in protein biosynthesis, a unique feature which has led to diverging ...

Pharmig News

05/21/2017 06:10:24 AM

The latest Pharmig News letter is now available.Members will have received a copy, non-members can purchase a copy via the Pharmig website.No. 67 – May 2017In this issue:Chairman’s NewsletterBook ReviewsThe Future Possibilities of Graphene ...

Maple syrup extract enhances antibiotic action

05/20/2017 07:30:09 AM

Antibiotics save lives every day, but there is a downside to their ubiquity. High doses can kill healthy cells along with infection-causing bacteria, while also spurring the creation of "superbugs" that no longer respond to known antibiotics. ...

The most beautiful bacteria you’ll ever see

05/19/2017 15:29:44 PM

Synthetic biologist Tal Danino manipulates microorganisms in his lab to create eye-catching, colorful patterns. Here’s a look at the process he uses to turn “Oh, yuck” into “Oh, wow.”TED are hosting a range of beautiful microbial images. ...

European Pharmacopoeia 9th Edition (Supplement 9.1)

05/19/2017 07:30:03 AM

The 1stsupplement to the 9th edition of the European Pharmacopeia became effective on 1st April 2017. Of interest to readers:Water for injections (0169)Production: revision to include purification processes equivalent to distillation (such as ...

Bacterial Identification Database Updated with Plant Pathogens

05/18/2017 07:30:00 AM

Biolog, Inc. have announced details of its latest GEN III identification database version 2.8, containing 1568 taxa, including 258 plant pathogens. This database update was completed by scientists at Biolog's headquarters in Hayward, CA in ...

Giant virus viewing required retrofitted microscope

05/17/2017 08:00:34 AM

In order to map one of the world’s largest viruses, scientists took a DIY approach to build a retrofitted cryo-electron microscope.“If the common cold virus is scaled to the size of a ladder, then the giant Samba virus is bigger than the ...

European Pharmacopoeia 9th Edition: Review of Supplement 9.2

05/16/2017 07:00:08 AM

Below is a list of monographs and general chapters that are new, or that have been revised, corrected or deleted for the 9th Edition (supplement 9.2). The implementation date is 1st July 2017.Revised texts            2.2.1    Clarity ...

Cleanroom Management in Pharmaceuticals and Healthcare (new edition)

05/15/2017 07:00:02 AM

Everything you need to know about the operation and management of cleanrooms – a new edition of the book edited by Tim Sandle and Madhu Raju Saghee is now available from Euromed Communications.In 26 Chapters and over 600 pages this book provides ...

Embracing the Cloud to Assure Data Integrity

05/14/2017 08:00:02 AM

Data integrity issues in the manufacturing of finished pharmaceuticals and active pharmaceutical ingredients (APIs) continue to be in the spotlight. Life sciences companies are under increased scrutiny by regulatory bodies, as the MHRA, FDA, ...

Nanoparticles Detect Deadly Viruses, Including Ebola

05/13/2017 07:00:28 AM

A system composed of two different types of nanoparticles can be used to accurately, sensitively, and quickly detect viruses.The earlier a viral infection is detected, the more effective the treatment. Currently available tests are accurate ...

Risk Mitigation When Evaluating Cleanroom Construction Materials

05/12/2017 07:30:09 AM

Maik Jornitz, President, G-Con, has written an interesting white paper on cleanroom construction materials.The introduction reads:Reducing the cost of goods sold has become a focus of pharmaceutical facility, cleanroom, and process design, ...

Mapping giant viruses

05/11/2017 07:30:45 AM

In a laboratory at Michigan State University, scientists took a DIY approach to build a retrofitted cryo-electron microscope that allowed them to map a giant Samba virus -- one of the world's largest viruses."If the common cold virus is scaled ...

How bacteria hunt other bacteria

05/10/2017 08:00:11 AM

A bacterial species that hunts other bacteria has attracted interest as a potential antibiotic, but exactly how this predator tracks down its prey has not been clear. A new study reveals that the bacterial predator Bdellovibrio bacteriovorus ...

Pharmaceutical Manufacturing: Understanding Your Process Series

05/09/2017 17:41:19 PM

New from PDA -  collected bestsellers in electronic book form covering three vital topics: Cleaning and Cleanrooms; Sterilization and Environmental Monitoring.These easily accessible, reasonably priced, informative collections offer background ...

Pharmeuropa 29.1

05/09/2017 07:00:17 AM

Pharmeuropa is a free online EDQM publication. Draft monographs are published in Pharmeuropa for public enquiry, which lasts for three months. Draft Monographs and General Texts for Comment.2.3.2    Identification of fatty oils by thin-layer ...

Pharmig Guide to Disinfectants

05/08/2017 07:00:15 AM

The Pharmig guide on disinfectants has been update and it captures the latest changes to global disinfection standards and provides updated best practice. The guide features a foreword by MHRA together with photographs and illustrations.The ...

Cleanroom Management - new book

05/07/2017 14:39:43 PM

New book - Cleanroom ManagementIn 26 chapters and over 600 pagesthis book provides a unique tool to help you achieve regulatory compliance. It first creates a foundation in history and established practice and then helps you understand how state ...

CDC Report on Incidence in Pathogens Transmitted Through Food for 2016

05/07/2017 14:13:25 PM

The CDC report describes surveillance data for 2016 nine pathogens (Campylobacter, Cryptosporidium, Cyclospora, Listeria, Salmonella, STEC, Shigella, Vibrio, and Yersinia. The data of 2016 is compared with the data from 2013-2015. FoodNet ...

US and Indian Pharmacopeias to collaborate

05/07/2017 08:00:24 AM

The US Pharmacopeial Convention (USP) announced on March 17, 2017 that it had signed a Memorandum of Understanding (MOU) with the Indian Pharmacopoeia Commission (IPC) in recognition of the two pharmacopeias’ collaboration in identifying ...

EMA Taskforce on Big Data

05/06/2017 07:00:33 AM

The European Medicines Agency (EMA) announced on March 23, 2017 that, along with heads of medicines agencies in the European Economic Area (EEA), it was establishing a taskforce to evaluate the use of big data to support pharmaceutical research, ...

Microbes evolved to colonize different parts of the human body

05/05/2017 08:00:26 AM

Microbes have evolved over millions of years to live in and on all parts of the human body. Scientists have created new ways to reconstruct how this evolution unfolded, using mathematical tools originally developed for geologists. They identified ...

Protist parasites - new species discovered

05/04/2017 08:00:01 AM

Tropical rainforests are one of the most species-rich areas on earth. Thousands of animal and plant species live there. The smaller microbial protists, which are not visible to the naked eye, are also native to these forests, where they live ...

Self-sustaining bacteria-fueled power cell created

05/03/2017 08:00:17 AM

Researchers at Binghamton University, State University of New York have developed the next step in microbial fuel cells (MFCs) with the first micro-scale self-sustaining cell, which generated power for 13 straight days through symbiotic interactions ...

Hidden structures in bacterial DNA revealed

05/02/2017 08:00:17 AM

Researchers have described the 3D structure of the genome in the extremely small bacteria Mycoplasma pneumoniae. They discovered previously unknown arrangements of DNA within this tiny bacteria, which are also found in larger cells. Their findings ...

Bacteria fed synthetic iron become electrical generators

05/01/2017 07:30:15 AM

Some species of bacteria can produce electricity; these are termed electrogenic bacteria. These organisms can produce a current as part of their metabolism. The term exoelectrogen refers to any microorganism with the ability to transfer electrons ...

Air pollution leads to more drug resistant bacteria

04/30/2017 12:30:00 PM

Research shows how black carbon affects bacteria in humans’ nose, throat and lungs, possibly affecting their ability to beat the immune system.An interesting article in The Guardian:“The study concluded that the resistance of communities ...

10 Easy Steps To Clean Spills In A Biosafety Cabinet

04/29/2017 08:00:27 AM

For over 40 years, NuAire has been providing laboratory equipment that better enables researchers to work under defined environmental conditions. A biosafety cabinet or biological safety cabinet (BSC) is an enclosed, ventilated laboratory workspace ...

TB Alliance Sublicenses Promising Anti-Tuberculosis Drug

04/28/2017 07:30:31 AM

TB Alliance and the Medicines Patent Pool (MPP) have announced a licensing agreement for the clinical development of sutezolid, an antibiotic drug candidate which demonstrated encouraging results in early studies. The sublicense pertains to ...

Tracking yellow fever virus replication

04/27/2017 07:00:51 AM

Yellow fever virus (YFV) is a member of the flavivirus family that also includes Dengue and Zika virus. The virus, which is thought to infect a variety of cell types in the body, causes up to 200,000 cases of yellow fever every year, despite ...

Fighting MRSA with membrane-busting compounds

04/26/2017 06:00:38 AM

According to the U.S. Centers for Disease Control and Prevention, every year at least 2 million people in America become infected by bacteria resistant to antibiotics, and 23,000 people die from such infections. Researchers have been working ...

Changes in gut microbiota after unhealthy diet examined

04/25/2017 07:30:16 AM

The intestine is covered with a plethora of microorganisms, collectively termed gut microbiota, that are thought to play an important role in regulating the metabolism and shaping the immune system. Many studies have shown that dysbiotic bacteria ...

Efficient microbial fuel cell made from paper

04/24/2017 07:30:26 AM

Fuel cells are one of the renewable sources of energy being actively worked on by scientists. The basis of many fuel cells are specific bacteria, and a new breakthrough has been made using a paper-based system.The search for alternative forms ...

Medical technologists find cheaper way to make essential medicine

04/23/2017 07:00:05 AM

Medical technologists have found a means to create an anti-fungal medication, designed to combat Cryptococcal meningitis, less expensively. The drug is intended for use in parts of Africa.A fungal form of meningitis causes a major problem in ...

Teixobactin: A Powerful Tool for Combating Resistant Strains

04/22/2017 07:30:06 AM

Resistance to antibiotics has grown out to be serious health dilemma. Despite this serious health crisis, no new antibiotics have been revealed since last 30 y. A new ray of hope in the form of teixobactin has come out of the dark which can ...

Preparation, production, storage and performance testing of culture media

04/21/2017 15:15:19 PM

Spotlight on ISO 11133:2014 “Microbiology of food, animal feed and water -- Preparation, production, storage and performance testing of culture media.”Culture media is of fundamental importance for most microbiological tests: to obtain pure ...

Light rain can spread soil bacteria far and wide

04/20/2017 07:30:31 AM

Using high-resolution imaging, researchers from MIT's Department of Mechanical Engineering observed the effect of raindrops falling on dry soil laden with bacteria. When falling at speeds mimicking those of a light rain, at temperatures similar ...

Faster, more accurate detection of food- and water-borne bacteria

04/19/2017 08:00:25 AM

Recently, Charles S. Henry and colleagues developed a paper-based method to detect Salmonella, Listeria and E. coli in food and water samples. In their latest study, Henry's team wanted to see if it would be feasible to use this paper-based ...

Visualizing the genome: First 3-D structures of active DNA created

04/18/2017 08:00:00 AM

Researchers from the University of Cambridge and the MRC Laboratory of Molecular Biology used a combination of imaging and up to 100,000 measurements of where different parts of the DNA are close to each other to examine the genome in a mouse ...

Understanding the Importance of Safety in Pharmaceutical Manufacturing and Transportation

04/17/2017 12:49:11 PM

Pharmaceutical manufacturing and transportation is an industry that requires a high level of oversight to make sure the medications being manufactured meet the required specifications and that they are being transported correctly to ensure maximum ...

Microbial swab recovery

04/17/2017 07:30:15 AM

Swabs are commonly used as part of microbiological environmental monitoring programmes and it is important to understand the suitability of the swabs used and their limitations.A new paper by Ravikrishna Satyada and Tim Sandle looks into this ...

'Smart' bacteria remodel their genes to infect our intestines

04/16/2017 07:30:20 AM

Infectious diarrhea, a common disease of children, is responsible for over 2 million infant deaths annually in developing counties alone. A primary cause of this and other devastating conditions is enteropathogenic bacteria, which attack the ...

Proposed New USP General Chapter: The Analytical Procedure Lifecycle ?1220?

04/15/2017 07:30:12 AM

The following may be of interest to readers:An analytical procedure must be demonstrated to be fit for its intended purpose. It is useful to consider the entire lifecycle of an analytical procedure, i.e., its design and development, qualification, ...

Humidity Measurement for Effective Manufacturing

04/14/2017 07:30:08 AM

The purpose of this free eBook is to share humidity theory, tools and practical examples of how measuring humidity, moisture and dew point brings value to different manufacturing processes.The eBook includes some of our most popular and requested ...

3-D tissue culture models to mimic human gut infections

04/13/2017 08:00:25 AM

Central to the development of tissue models that can better predict how humans respond to infection is the understanding that cells and tissues in our bodies function in a three-dimensional (3-D) context. Accordingly, cell-based models of tissues ...

Useful links updated

04/12/2017 09:28:29 AM

The list of useful links to science and regulatory organizations on the site has been updated. Please check through, there will be something of interest.A3P (pharmaceutical industry, biotechnological and biomedical response to rapidly changing ...

Phage therapy shown to kill drug-resistant superbug

04/12/2017 08:00:08 AM

Phages are viruses that kill bacteria but are otherwise harmless. A major advantage is that phages only target the harmful bacteria, so there are less side of the effects often associated with antibiotics. Phage therapy however has not had the ...

Beneficial bacteria can offset bowel disease

04/11/2017 08:00:24 AM

In a new report, researchers describe how inflammation can go unchecked in the absence of a certain inhibitor called NLRP12, adding that beneficial bacteria may be the key to helping to reverse a cycle of gut inflammation seen in certain in ...

Biodecontamination of Cleanrooms and Laboratories Using Gassing Systems

04/10/2017 14:26:36 PM

Tim Sandle has written a new article on the decontamination of cleanrooms and laboratories by gassing systems:Cleanrooms, laboratory areas, isolators and biosafety workspaces (microbiological safety cabinets) require a level of cleanliness and ...

New sensor detects inflammatory bowel disease

04/09/2017 07:00:07 AM

Inflammatory bowel disease refers to a set of inflammatory conditions of the colon and small intestine. Examples include Crohn's disease and ulcerative colitis. In the U.S. alone some one million people suffer with one type of the disease.Current ...

3-D tissue culture models to mimic human gut infections

04/08/2017 08:00:35 AM

Central to the development of tissue models that can better predict how humans respond to infection is the understanding that cells and tissues in our bodies function in a three-dimensional (3-D) context. Accordingly, cell-based models of tissues ...

Phage therapy shown to kill drug-resistant superbug

04/07/2017 07:30:01 AM

Phages are viruses that kill bacteria but are otherwise harmless. A major advantage is that phages only target the harmful bacteria, so there are less side of the effects often associated with antibiotics. Phage therapy however has not had the ...

Visualizing the genome: First 3-D structures of active DNA created

04/06/2017 07:30:32 AM

Researchers from the University of Cambridge and the MRC Laboratory of Molecular Biology used a combination of imaging and up to 100,000 measurements of where different parts of the DNA are close to each other to examine the genome in a mouse ...

Beneficial bacteria can offset bowel disease

04/05/2017 08:00:32 AM

In a new report, researchers describe how inflammation can go unchecked in the absence of a certain inhibitor called NLRP12, adding that beneficial bacteria may be the key to helping to reverse a cycle of gut inflammation seen in certain in ...

EDQM Symposium on Microbiology

04/04/2017 08:00:08 AM

The EDQM will hold an international symposium on 10-11 October 2017 in Strasbourg (France) to present and discuss recent achievements, as well as future perspectives, of the Ph. Eur. in the microbiology field.The symposium will cover the recent ...

Risk of microbial spores in cleanrooms

04/03/2017 07:30:11 AM

The risks posed by microbial spores pose to cleanrooms in terms of their survival mechanisms and, in the case of fungi, ease of dispersal, are substantial. One means to address this is through the use of a proven sporidical agent. This is the ...

ISO 31000 revision

04/02/2017 07:30:14 AM

ISO 31000:2009 on risk management is intended for people who create and protect value in an organization by managing risks, making decisions, setting and achieving objectives and improving performance. The standard’s revision process discovers ...

Microbiome diversity is influenced by chance encounters

04/01/2017 07:30:12 AM

Within the human digestive tract, there are trillions of bacteria, and these communities contain hundreds or even thousands of species. The makeup of those populations can vary greatly from one person to another, depending on factors such as ...

Takeaways From The FDA's Revised Quality Metrics Guidance

03/31/2017 07:00:22 AM

On November 23, 2016, the Food and Drug Administration (FDA) published a revised draft guidance for Submission of Quality Metrics Data. The guidance includes significant changes to the earlier quality metrics draft guidance issued by the agency ...

Risk Mitigation When Evaluating Cleanroom Construction Materials

03/30/2017 15:22:13 PM

Maik Jornitz, President, G-Con, has written an interesting white paper on cleanroom construction materials.The introduction reads:Reducing the cost of goods sold has become a focus of pharmaceutical facility, cleanroom, and process design, ...

Why rare microbial species are sometimes important

03/30/2017 07:30:15 AM

Despite the small population of each rare species in a microbial community, such species may number as much as several hundred within a community, such that the so-called "rare biosphere" may account for roughly 20-30 percent of individual bacteria ...

Targeting antimicrobial resistance in the short-term

03/29/2017 07:30:11 AM

While any antimicrobial resistance is concerning, the increasing incidence of antibiotic-resistant Gram-negative bacteria has become a particular problem as strains resistant to multiple antibiotics are becoming common and no new drugs to treat ...