Cleanroom summit

08/15/2017 07:00:37 AM

The Cleanroom Management Summit would like to highlight Annex 1 compliance, audit readiness and isolator technology as the essential topics for the pharmaceutical and healthcare industries. Included in the Summit’s Agenda they will result ...

Validation and Assessment of Computerized System Software in a Pharmaceutical Facility

08/14/2017 14:54:43 PM

Validation is an established approach within pharmaceuticals and healthcare, and the principles of validation extend to computerized systems. Validation concerns establishing documented evidence designed to produce a high degree of assurance ...

Pharmig News

08/13/2017 07:35:41 AM

The latest edition of Pharmig News has been published. This is edition #68.Inside the issue is part 1 of Pharmig’s survey of best practices for culture media, a regulatory news round-up, the chairman’s perspective, review of ‘Making P ...

FDA unveils plan to eliminate orphan designation backlog

08/13/2017 07:00:15 AM

U.S. Food and Drug Administration unveiled a strategic plan to eliminate the agency’s existing orphan designation request backlog and ensure continued timely response to all new requests for designation with firm deadlines. The agency’s ...

Pharmig News #67

08/13/2017 06:37:46 AM

Pharmig Newsletter #67 by Tim Sandle on ScribdPosted by Dr. Tim SandlePharmaceutical Microbiology (c) Dr Tim Sandle http://www.pharmamicroresources.com

Single Entity Injectable Drug Products

08/12/2017 08:00:21 AM

The FDA is requiring the removal of ratio expressions of strength from the labeling of single-entity injectable drug products (i.e., drug products that contain only one active ingredient) and replacement with the amount per unit of volume (e.g., ...

Designing cleanrooms for particulate control (Turkish)

08/11/2017 08:00:20 AM

Tim Sandle has written an article for the Turkish Cleanroom News publication - Designing cleanrooms for particulate control (Turkish: Parçac?k kontrolü için temiz oda tasar?m?).The reference is:Sandle, T. (2017) Designing cleanrooms for ...

Supply Chain Security Toolkit for Medical Products

08/10/2017 07:30:23 AM

News from the FDA:Protecting the integrity of the medical product supply chain is complex and requires a global approach. FDA led a collaboration within Asia Pacific Economic Cooperation (APEC) economies to create a Supply Chain Security Toolkit ...

GMP Short Notice and Unannounced Inspections

08/09/2017 07:30:13 AM

An interesting blog post from the UK MHRA:The Human Medicines Regulations 2012 as amended; regulation 325 ‘Rights of Entry’ states that an inspector may at any reasonable time enter premises. This allows for the MHRA to perform inspections ...

Guidance for stem cell therapies in animals

08/08/2017 08:00:11 AM

The European Medicines Agency (EMA) has published the first ever guidance document for stem cell therapies in animals. The guidance addresses concerns raised by manufacturers and authorities in regard to the sterility (absence of bacteria, fungi ...

New book: Aseptic and Sterile Processing: Control, Compliance and Future Trends

08/07/2017 15:20:37 PM

New book: Aseptic and Sterile Processing: Control, Compliance and Future Trends. Edited by Tim Sandle and Edward C. Tidswell.Sterile medical products comprise of medical devices, drugs, and biologics. Some are completed  by a terminal ste ...

Santitization of Pharmaceutical Facilities

08/07/2017 08:00:10 AM

A new paper on cleaning and disinfecting pharmaceutical and healthcare facilities has been published. Here is the abstract:Maintaining environmental control including microbiological contamination in a pharmaceutical manufacturing environment ...

Teixobactin - new antibiotic update

08/06/2017 07:30:14 AM

Scientists have produced new, effective and simplified forms of teixobactin - a new generation antibiotic which defeats multi-drug resistant infections such as MRSA - as part of a pioneering research effort to tackle antimicrobial resistance.The ...

EU report on antimicrobial resistance

08/05/2017 08:00:09 AM

Following a top level EU report showing antimicrobial resistance (AMR) remains high, Professor Mike Catchpole, Chief Scientist at the European Centre for Disease Prevention and Control (ECDC), has warned that stricter use of antibiotics is ...

The world is underprepared for infectious diseases

08/04/2017 08:00:06 AM

A team of international experts has highlighted how the world remains ‘grossly underprepared’ for infectious disease outbreaks, which are likely to become more frequent in future decades.Led by Professor Suerie Moon at the Graduate Institute ...

New test measures how long it takes to kill bacteria

08/03/2017 07:00:21 AM

A simple new method has been developed for measuring the time it takes to kill a bacterial population could improve the ability of clinicians to effectively treat antimicrobial-tolerant strains that are on the path to becoming resistant.According ...

Bacterial classification remains elusive

08/02/2017 07:30:08 AM

New research from Dartmouth College raises questions over how scientists should interpret observed groupings of bacteria. The study advises caution with the assumption that bacterial clusters are always a result of ecological and genetic forces.The ...

Gut bacteria play a key role in regulating abdominal pain

08/01/2017 15:18:32 PM

Visceral pain is a global term used to describe pain originating from the internal organs of the body, which affects a significant proportion of the population and is a common feature of functional gastrointestinal disorders such as irritable ...

The pathologic appendix

07/31/2017 14:04:58 PM

Antonella Chesca and Tim Sandle have written an article looking at the pathologic appendix.Here is the abstract:Appendix pathology brings together different forms and is found in different age segments. Most susceptible to disease are children. ...

Battling infections with bioelectricity

07/30/2017 08:00:17 AM

Is the answer to fighting pathogens connected with bioelectricity? Promising new research suggest this is possible by using drugs to changing electrical charge of cells. Studies have been performed in frogs.What is remarkable about the studies ...

Bacterial pathogens interact to cause disease

07/29/2017 08:00:11 AM

New methodology allowed researchers to more easily investigate mechanisms of infection and provide new insight into how pathogens can work together to cause disease. Using the new tool, researchers confirmed a safer model for study of Brucella ...

Aseptic and Sterile Processing: Control, Compliance and Future Trends

07/28/2017 15:39:23 PM

The Aseptic and Sterile Processing: Control, Compliance and Future Trends is the most important text discussing aseptic and sterile manufacturing that has been published in the last decade! This text looks at both today and tomorrow in regard ...

New approach to battle drug-resistant bacteria

07/28/2017 07:30:05 AM

Researchers at University of Utah Health have developed a rapid screening method to identify beneficial pairs of existing FDA-approved drugs to combat multi-drug resistant (MDR) bacterial infections. The microbiologists analyzed a bacterial ...

EMA issues guidance document in preparation for Brexit

07/27/2017 06:30:36 AM

The European Medicines Agency (EMA) and the European Commission have published guidance to help pharmaceutical companies prepare for the United Kingdom’s withdrawal from the European Union.The question-and-answer document contains information ...

Moist-heat sterilization of blood bags

07/26/2017 07:30:18 AM

The most suitable type of autoclaves for sterilizing blood bag systems are autoclaves in which sterilizing medium is a mixture of steam and air. This method, one of the counter pressure types of sterilization, is also called ‘air-over-steam’. ...

High prevalence of CRE in Washington, D.C.

07/25/2017 07:30:28 AM

Carbapenem-resistant Enterobacteriaceae (CRE), a family of highly pathogenic antibiotic-resistant organisms, are endemic across Washington, D.C. healthcare facilities, with 5.2 percent of inpatients testing positive for the bacteria, according ...

Chronic obstructive pulmonary disease

07/24/2017 07:30:05 AM

Antonella Chesca and Tim Sandle have written an article looking at chronic obstructive pulmonary disease.Here is the abstract:The present study refers to the exploration of the respiratory function of patients who presented acute symptoms of ...

New antibiotic effective against drug-resistant bacteria

07/23/2017 07:00:27 AM

Scientists have discovered a new antibiotic effective against drug-resistant bacteria: pseudouridimycin. The new antibiotic is produced by a microbe found in a soil sample collected in Italy and was discovered by screening microbes from soil ...

Bacteria from hot springs solve mystery of metabolism

07/22/2017 07:30:12 AM

Combustion is often a rapid process, like fire. How can our cells control the burning process so well? The question has long puzzled researchers. Using bacteria from hot springs, researchers from Stockholm University now have the answer.Light ...

New health and safety standard

07/21/2017 07:30:22 AM

A new International Standard due out early next year – ISO 45001. This is ISO’s first standard for occupational health and safety management systems.According to ISO: “ISO 45001, Occupational health and safety management systems – R ...

European Pharmacopoeia revises Biological Indicator Chapter

07/20/2017 07:00:00 AM

The general chapter in the European Pharmacopoeia (5.1.2) relating to biological indicators has undergone a significant revision. The new version has been issued with the release of supplement 9.2 to the 9th edition of the pharmacopoeia (1). ...

What's that smell?

07/19/2017 07:00:32 AM

Did you know that bacteria make us humans and other animals smell the way we do? On top of that, animals use that smell to communicate with each other. The “fermentation hypothesis of chemical recognition” says that bacteria in the scent ...

Genetic Data for 1000 Microbes Released

07/18/2017 07:00:21 AM

Microbial organisms are a major component of our environment, but scientists have only begun to study their genetic composition in depth. Using current genetic technologies, researchers with the U.S. Department of Energy Joint Genome Institute ...

Pathological appendix versus normal appendix

07/17/2017 07:30:02 AM

Antonella Chesca and Tim Sandle have written a paper of interest to those working in pathology or medicine. It concerns the pathological appendix compared with the normal appendix.Here is the abstract:This article makes reference to certain ...

Quality Risk Management for Manufacturing Systems

07/16/2017 06:00:22 AM

PDA has issued a new technical report of interest. The title is “•      PDA Technical Report No. 54-5 (TR 54-5) Quality Risk Management for the Design, Qualification, and Operation of Manufacturing Systems.”“This technical report ...

Swirling swarms of bacteria offer insights on turbulence

07/15/2017 08:00:19 AM

When bacteria swim at just the right speed, swirling vortices emerge. As those patterns disintegrate into chaos, physicists detect a telling mathematical signature.In physical systems, turbulence emerges when the smooth flow of a liquid or gas ...

Fungi assess radioactivity in soil

07/14/2017 17:47:25 PM

The Environmental Radioactivity Laboratory of the UEx has carried out a study to quantify radioactive presence in fungi. According to the research, this quantification is made using transfer coefficients that compare the radioactive content ...

First human antibodies to work against all Ebola viruses

07/13/2017 08:00:06 AM

After analyzing the blood of a survivor of the 2013-16 Ebola outbreaks, a team of scientists from academia, industry and the government has discovered the first natural human antibodies that can neutralize and protect animals against all three ...

Modified experimental vaccine protects monkeys from malaria

07/12/2017 08:00:06 AM

Researchers have modified an experimental malaria vaccine and showed that it completely protected four of eight monkeys that received it against challenge with the virulent Plasmodium falciparum malaria parasite. In three of the remaining four ...

Bioelectricity - a new weapon to fight infection

07/11/2017 07:30:24 AM

Changing natural electrical signaling in non-neural cells improves innate immune response to bacterial infections and injury. Tadpoles that received therapeutics, including those used in humans for other purposes, which depolarized their cells ...

Structural aspects of tonsillitis

07/10/2017 07:30:09 AM

Antonella Chesca and Tim Sandle have produced a new paper of interest in relation to medicine, focusing on tonsillitis. The abstract reads:The present study shows structural issues relating to various forms of tonsillitis, frequently encountered ...

Smartphone microscope creates interactive tool for microbiology

07/09/2017 07:00:01 AM

A new 3-D printed, easily assembled smartphone microscope developed at Stanford University turns microbiology into game time. The device allows kids to play games or make more serious observations with miniature light-seeking microbes called ...

Why antibiotics fail

07/08/2017 08:00:17 AM

When a patient is prescribed the wrong antibiotic to treat a bacterial infection, it's not necessarily the physician who is at fault. The current antibiotic assay -- standardized in 1961 by the World Health Organization and used worldwide -- ...

Shift in gut microbes after surgery

07/07/2017 08:00:06 AM

Obesity is linked with the composition of microbes in the human gut. In new research, bacterial composition in the gut, as well as accompanying metabolites are shown to undergo a profound and permanent shift, with microbial diversity significantly ...

PHARMACOPEIAL FORUM VOL. 43 No.2

07/06/2017 08:00:15 AM

News from the USP Pharmacopeial Forum:Chapter 1231 “Water for Pharmaceutical Purposes” (Revision proposal target, USP41-NF36 1st Supplement)Proposed revisions are as follows:Add information to the section on Sampling for microbial and chemical ...

Bacteria used as cancer drug factories

07/05/2017 07:30:01 AM

Researchers have developed a method of producing P450 enzymes -- used by plants to defend against predators and microbes -- in bacterial cell factories. The process could facilitate the production of large quantities of the enzymes, which are ...

Predatory bacteria kills multi-drug resistant bacteria on eyes

07/04/2017 08:00:06 AM

Scientists have developed a new method to clear antibiotic resistant bacteria from the surface of the eye -- introducing a new strain of bacteria that preys on other microorganisms. The research is being presented at the 2017 Annual Meeting ...

Tim Sandle Q&A

07/03/2017 07:30:21 AM

Tim Sandle has been interviewed by the Institute of Validation Technology as part of the ‘Meet the Board’ series (Dr Sandle is a regular contributor to the IVT Network).Here is an extract:What is your advice to people who want to begin ...

Probing insight into antimicrobial resistant fungus

07/02/2017 15:09:00 PM

A major systematic review of the pathogenic fungus Candida auris has been conducted. This yeast-like fungus has been found in hospitals and it is resistant to several classes of antimicrobial drugs. This poses serious risks for those infected.A ...

Gut microbiome predicts response to therapy for inflammatory bowel disease

07/01/2017 08:00:22 AM

Researchers have identified differences in the composition and the function of the gut microbiome between patients for whom treatment with a monclonal antibody-based drug was effective in inducing remission of inflammatory bowel disease symptoms ...

International Group B Strep Throat Awareness Month

07/01/2017 07:30:31 AM

Group B Streptococcus (GBS) is a bacteria that’s naturally found in the digestive and lower reproductive tracts of both men and women. Approximately 1 in 4 pregnant women carry GBS, and the U.S. Centers for Disease Control and Prevention ...

Market pressures hampering access to essential antibiotics

06/30/2017 08:00:11 AM

Antibiotics used to treat a variety of common bacterial infections are becoming more difficult to access, mostly because the drugs are less profitable for manufacturers to produce and market.Writing in a commentary in Clinical Microbiology and ...

Another Major Ransomware Attack Spreading

06/30/2017 06:37:11 AM

Another major ransomware attack is currently spreading around the world. According to Motherboard, "a wide range of private businesses" were affected on this week, though it's unclear whether all the attacks are related.Reuters Tech News posted ...

Urine test for Zika virus

06/29/2017 08:00:20 AM

There is no vaccine. No medication. And, no quick, reliable test for Zika virus … until now. Babies born with the virus often have lifelong, devastating birth defects. Testing for the virus currently involves trained medical staff drawing ...

EMA and heads of national competent authorities discuss consequences of Brexit

06/28/2017 07:30:21 AM

The European Medicines Agency (EMA) organised an information meeting yesterday with members of its Management Board and heads of the National Competent Authorities (NCAs) of the EU/EEA Member States. The goal was to start discussing how the ...

Computer Systems Validation

06/27/2017 07:30:16 AM

The MHRA are continuing their series on data integrity and computer systems validation. The latest blog post has some useful information (this time from Balall Naeem), such as:If you are able to obtain validation documentation here are some ...

Microbiological monitoring of pharmaceutical water systems

06/26/2017 13:50:19 PM

Water is widely used in pharmaceutical manufacturing; either as a raw material, as an ingredient, or as a final product. Water is also used for rinsing equipment or for the preparation of disinfectants and detergents. These applications require ...

MHRA GMP Inspection Deficiency Data Trend 2016

06/25/2017 07:30:15 AM

The GMDP Inspectorate has improved the way of gathering the inspection deficiency data for 2016. The new data trending can allow industries to identify:The severities and frequencies by the EU GMP referencesThe overall number of deficiencies ...

Silver Bullet Against MRSA: Silver Ion-coated Devices

06/24/2017 07:30:24 AM

Methicillin-resistant Staphylococcus aureus (MRSA) infections are caused by a type of staph bacteria that has become resistant to the antibiotics used to treat ordinary staph infections. The rise of MRSA infections is limiting the treatment ...

Chemical purity regulatory findings

06/23/2017 13:52:47 PM

New Applications for Certificates of Suitability (CEP) for chemical purity (Top 10 deficiencies)The EDQM has issued a document that summarises the ten most frequent questions raised after the initial evaluation of new applications for Certificates ...

Guidance on quality of water for pharmaceutical use

06/22/2017 07:00:26 AM

Concept paper on the need for revision of note for guidance on quality of water for pharmaceutical useUp to now, the production of Water for Injections (WFI) had been limited to distillation only. The revision of the monograph for Water for ...

Why we get diarrhea

06/21/2017 17:07:48 PM

Does diarrhea serve a purpose? Does it actually help clear the bacteria causing a gastrointestinal infection, or is it merely a symptom of disease that should be prevented as much as possible? In a new study from Brigham and Women's Hospital, ...

Test for Abnormal Toxicity

06/21/2017 07:00:29 AM

The scientific validity and rationale of the test for abnormal toxicity has been the subject of debate for some time in Europe. The test was originally developed for detecting external contaminants in biological products, but over time the ...

FDA - Burkholderia cepacia complex poses a contamination risk

06/20/2017 07:00:10 AM

FDA warned drug manufacturers on May 22, 2017 about a series of product recalls involving Burkholderia cepacia complex (BCC) contamination. BCC is a water-borne pathogen that can be found in pharmaceutical water systems. According to FDA, it ...

Risk assessment and pharmaceutical processing hazards

06/19/2017 07:00:11 AM

Pharmaceutical medicines are expected to be efficacious and to perform according to the product licence or as directed by the medical practitioner. Medicines are also expected to be safe, and the basis of a safe medicine is one that has been ...

Continuous Manufacturing Provides Many Benefits for the Pharmaceutical Industry

06/18/2017 10:06:18 AM

Continuous manufacturing is a process people adopted since the beginning of the industrial revolution — production for a product continues for months or years uninterrupted, creating an unbroken supply chain. It’s used in everything from ...

Antibiotics are a potential link to bowel cancer precursor

06/18/2017 09:27:23 AM

A new study has found that people who take antibiotics over long time are more at risk of developing growths on the bowel that could be a precursor to cancer.The research forms part of a wider line of scientific inquiry about the effect that ...

Can airborne viruses survive in water?

06/17/2017 07:30:27 AM

A new study challenges the tenet that herpes viruses, like most enveloped viruses, are relatively unstable outside their host. Under a variety of conditions equine herpesvirus remained stable and infectious over a three week period. This suggests ...

Foods as a potential source of spread of Clostridium difficile

06/16/2017 07:30:28 AM

Foods should be investigated as a potential source of spread of Clostridium difficile, according to research presented at the 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID).C. difficilecauses gut infections ...

Ocean acidification impairs the nitrogen-fixing bacteria

06/15/2017 07:00:30 AM

While increased carbon dioxide levels theoretically boost the productivity of nitrogen-fixing bacteria in the world's oceans, because of its "fertilizing" effect, a new study reveals how increasingly acidic seawater featuring higher levels of ...

Guide to the preparation, use and quality assurance of blood components (new version)

06/14/2017 08:00:07 AM

The EDQM have issued the 19th Edition of the ‘Guide to the preparation, use and quality assurance of blood components’ (Blood Guide). The 19th Edition of the Guide contains an updated version of the Good Practice Guidelines to fully reflect ...

Novel antibiotic resistance gene in milk

06/13/2017 07:30:15 AM

A new antibiotic resistance gene has been found in bacteria from dairy cows. This gene confers resistance to all beta-lactam antibiotics including the last generation of cephalosporins used against methicillin-resistant Staphylococcus aureus. ...

Chronic fatigue syndrome linked to imbalanced microbiome

06/12/2017 07:30:08 AM

Scientists at the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health have discovered abnormal levels of specific gut bacteria related to chronic fatigue syndrome/myalgic encephalomyelitis, or ME/CFS, ...

Giardiasis may be a disease of the ecology of the GI tract

06/11/2017 08:00:02 AM

Colonization by the human and animal parasite, Giardia, changed the species composition of the mouse microbiome in a way that might be harmful."This shift is generally characterized by more aerobic bacteria and less diversity of anaerobic species ...

Oldest ever microbial fossils discovered

06/10/2017 08:00:35 AM

Remains of microorganisms, said to be over 3,770 million years old, have been discovered. These remnants provide conclusive evidence of the age of one of the oldest life forms on Earth.#The discovery of the microbial fossils, in Canada, has ...

Intestinal bacteria may protect against diabetes

06/09/2017 08:00:08 AM

Medical research suggests that a high concentration of indolepropionic acid in serum helps to protect a person against type 2 diabetes. Indolepropionic acid is produced by intestinal bacteria, and it is higher with a fiber-rich diet.The new ...

Insight into pathogenic bacterium Pseudomonas aeruginosa

06/08/2017 08:00:09 AM

Researchers have identified how the pathogenic bacterium Pseudomonas aeruginosa uses tension-activated membrane channels to stop itself from swelling up and bursting when it is suddenly exposed to water. The study helps explain how this bacterium ...

Reducing animal testing in Europe

06/07/2017 08:00:22 AM

The European Medicines Agency has produced a position paper titled “Reflection paper providing an overview of the current 4 regulatory testing requirements for medicinal products for 5 human use and opportunities for implementation of the ...

Endotoxin mediated toxic anterior segment syndrome in ophthalmic products

06/05/2017 07:30:36 AM

Specifically endotoxin contamination of ophthalmic medical devices and intraocular ophthalmic products can cause ‘toxic anterior segment syndrome’ (TASS). This is an acute inflammation of the eye following ocular lens replacement surgery. ...

USP Chapter 1224 for Transfer of Analytical Methods

06/04/2017 12:29:25 PM

When validated methods are transferred between laboratories and sites, their validated state should be maintained to ensure the same reliable results in the receiving laboratory. So far there has not been an official guidance on what exactly ...

Utility Qualification Vol. II

06/04/2017 07:30:30 AM

IVT (2017) Utility Qualification Vol. II, Institute of Validation Technology, USA:The impact of water on daily activities within the production facility is significant and therefore, the ability to receive and maintain high quality water on ...

Ozonated water

06/03/2017 07:00:24 AM

Ozonated water systems are available in handwashing sinks, mobile portable ozonated water generators, and in-line skid systems. Some of the portable ozonated water units have been used to clean walls, tanks, filling lines, floors, and the actual ...

High-resolution imaging with conventional microscopes

06/02/2017 08:00:23 AM

Researchers have developed a way to make extremely high-resolution images of tissue samples, at a fraction of the cost of other techniques with similar resolution. Known as iterative expansion microscopy, relies on expanding tissue repeatedly, ...

Disrupting bacteria to better treat infections

06/01/2017 08:00:46 AM

While scientists rush to discover new antibiotics, bacteria fight back by developing new tools to resist antibiotics. In recent years, the bacteria have been winning.So this paradigm led researchers at NSU to take another look at how bacteria ...

Newly-discovered gene that makes bacteria resistant to the most powerful antibiotics

05/31/2017 07:30:18 AM

A disturbing new gene that can make normal bacteria resistant to the strongest antibiotics has been detected in Canada, it had been revealed.From The Independent:The gene, MCR-1, is notable because it produces a chemical that makes bacteria ...

How Gonorrhea manipulates the female reproductive tract

05/30/2017 07:00:19 AM

Gonorrhea is a widespread sexually transmitted disease caused when Neisseria gonorrhoeae bacteria infect the normally protective inner lining of human genital tissues. In women, the opening of the uterus, known as the endocervix, serves as a ...

Biosimilars (EDQM News)

05/28/2017 07:30:10 AM

EDQM Biosimilars: Ph. Eur. monographs are flexible and evolving standards During a seminar co-organised with the European Medicines Agency (EMA), the EDQM clarified further the role that Ph. Eur. monographs play in the assessment of biosimilars. ...

Synthetic biologists engineer inflammation-sensing gut bacteria

05/27/2017 08:00:17 AM

Synthetic biologists at Rice University have engineered gut bacteria capable of sensing colitis, an inflammation of the colon, in mice. The research points the way to new experiments for studying how gut bacteria and human hosts interact at ...

EMA: risk based prevention of cross contamination in production

05/26/2017 08:00:30 AM

The European Medicines Agency has issued a new document, with the lengthy title of “Questions and answers on implementation of risk based prevention of cross contamination in production and ‘Guideline on setting health based exposure limits ...

New assay for bioterrorism threat

05/25/2017 13:29:24 PM

Researchers in Spain are using RPA as the foundation for a highly sensitive and specific solid-phase optical assay that can detect the potential biowarfare agent, Y. pestis, in less than an hour. The enzyme-linked oligonucleotide assay (ELONA) ...

Researchers uncover how bacteria burst our cells

05/25/2017 07:00:33 AM

Scientists based in Vienna unveil the complex molecular structure that causes lethal infections by Mycobacterium tuberculosis (Mtb). Their findings might have implications for potential therapies against antibiotic-resistant tuberculosis. The ...

Too much pressure: a behavioral approach to Data Integrity

05/24/2017 07:30:08 AM

The MHRA has published an interesting article on the behavioral factors that shape data integrity.Data integrity refers to maintaining and assuring the accuracy and consistency of data over its entire life-cycle, and is a critical aspect to ...

How a beneficial gut microbe adapted to breast milk

05/23/2017 07:30:13 AM

Breast milk provides vital nutrients not only to infants, but also to beneficial microbes that inhabit the gastrointestinal tract. A new study shows that a bacterial species called Bifidobacterium longum has successfully adapted to the unique ...

Pharmig Guide to Cleanrooms

05/22/2017 07:00:17 AM

Pharmig has issued a new publication relating to cleanrooms. The guide covers good cleanroom design (together with suitable operational parameters), cleanroom specifications, microbial control, and classification according to the international ...

Giant viruses found in Austrian sewage

05/21/2017 08:00:19 AM

Giant viruses are characterized by disproportionately large genomes and virions that house the viruses' genetic material. They can encode several genes potentially involved in protein biosynthesis, a unique feature which has led to diverging ...

Pharmig News

05/21/2017 06:10:24 AM

The latest Pharmig News letter is now available.Members will have received a copy, non-members can purchase a copy via the Pharmig website.No. 67 – May 2017In this issue:Chairman’s NewsletterBook ReviewsThe Future Possibilities of Graphene ...

Maple syrup extract enhances antibiotic action

05/20/2017 07:30:09 AM

Antibiotics save lives every day, but there is a downside to their ubiquity. High doses can kill healthy cells along with infection-causing bacteria, while also spurring the creation of "superbugs" that no longer respond to known antibiotics. ...

The most beautiful bacteria you’ll ever see

05/19/2017 15:29:44 PM

Synthetic biologist Tal Danino manipulates microorganisms in his lab to create eye-catching, colorful patterns. Here’s a look at the process he uses to turn “Oh, yuck” into “Oh, wow.”TED are hosting a range of beautiful microbial images. ...

European Pharmacopoeia 9th Edition (Supplement 9.1)

05/19/2017 07:30:03 AM

The 1stsupplement to the 9th edition of the European Pharmacopeia became effective on 1st April 2017. Of interest to readers:Water for injections (0169)Production: revision to include purification processes equivalent to distillation (such as ...

Bacterial Identification Database Updated with Plant Pathogens

05/18/2017 07:30:00 AM

Biolog, Inc. have announced details of its latest GEN III identification database version 2.8, containing 1568 taxa, including 258 plant pathogens. This database update was completed by scientists at Biolog's headquarters in Hayward, CA in ...