Following a stimulating discussion with Jon Brock on the variability of the phenotype in autism and dyslexia, I thought I would explore a little more the influence of randomness on the phenotypic expression of mutations affecting neurodevelopmental processes. I have written about this before, in general terms, but here want to discuss one particular aspect – how probabilistic inheritance of a defect at a cell biological level is played out across the brain and how this influences the emergent phenotype of the individual.

read more: Probabilistic inheritance and neurodevelopmental phenotypes: location, location, location