The amyotrophic lateral sclerosis, also known as Lou Gehrig's syndrome, is a disease characterized by the degeneration of the anterior horns of the spinal cord and medulla oblongata nuclei associated with degeneration of the direct pyramidal tracts. Amyotrophic lateral sclerosis causes spastic paraplegia (paralysis of the lower limbs) and muscular atrophy. The evolution of this disease is chronic, usually ending in death in a time span of 6 to 7 years. The cause of this syndrome is unkown.

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