The Houston Texans will have a great opportunity to stake out their claim on the AFC South and a playoff berth with their 2010 NFL schedule starting September 12th in an opener against their division rival and AFC champion the Indianapolis Colts. A game at a weak Washington Redskins team follows on September 19th. The Dallas Cowboys will visit Houston on September 26th in a highly anticipated All-Texas affair that will get plenty of NFL betting action at sportsbooks which is followed by an October 3rd game at the Oakland Raiders. Online sportsbooks have the Texans 28-1 longshots in 2011 Superbowl odds to win the championship, 14-1 to win the AFC conference and have an over/under regular season win total of 8.5 UNDER (-135).

Houston will host the hungry New York Giants on October 10th and then have a winnable game in NFL odds vs the Kansas City Chiefs team on October 17th before taking week 7 off with a bye. The Texans return to the 2010 NFL schedule in week 8 with a rematch vs the Colts at Indianapolis on Monday Night football. The second half of the 2010 Texans schedule kicks off with a tough home game against the AFC West champion San Diego Chargers followed by a road game at the Jacksonville Jaguars on November 14th. The Texans will then travel to New York to face the Jets on November 21st in a match-up against one of the top favorites to win the AFC conference.

The Tennessee Titans will visit Houston on November 28th in what could be one of the biggest match-ups in the AFC South this season. That is followed by a December 2nd match-up at Philadelphia on a Thursday night. The final and critical quarter of the Texans 2010 NFL schedule starts at home against a highly touted and loaded Baltimore Ravens team on December 13th. Houston then travels to Tennessee with a rematch against the Titans on December 19th. Another road game at Denver is set for December 26th before the season finale at home against Jacksonville on January 2nd.